Approved Studies
Studies requesting data from the OPC Research Database must undergo protocol approval via ADEPT before any data access is granted. ADEPT is an independent body of experts who ensure the database is only utilised as part of projects that adhere to high standards of confidentiality, scientific rigour, and ethical integrity.
Below is an index of protocols approved to use the OPCRD. Filter by year in the right-hand column and click on protocols for further information (coming soon).
Following publication, peer-reviewed articles using OPCRD data are listed on our publications page.
The UVAC study: Understanding Variation in Admissions from Care Homes.
Organisation:
National Institute for Health and Care Research (NIHR) Academy
Study Registration:
Approval Date:
29 January 2025
ADEPT:
ADEPT0325
SGLT2 inhibitor utilisation in adults with chronic kidney disease, type 2 diabetes mellitus and chronic heart failure in the UK.
Organisation:
Lane Clark and Peacock
Study Registration:
Approval Date:
20 January 2025
ADEPT:
ADEPT0125
Investigating the effectiveness of interventions that improve medication adherence in school-aged children with asthma.
Organisation:
University of Sheffield
Study Registration:
Approval Date:
19 April 2024
ADEPT:
ADEPT0524
Phenotyping Asthma Exacerbations in primary care: an electronic medical record study (PHASE).
Organisation:
University of Oxford
Study Registration:
Approval Date:
5 December 2024
ADEPT:
ADEPT2024
Development of a prediction model to identify Neuroendocrine tumours (NET), based on UK electronic primary healthcare records.
Organisation:
Volv Global SA
Study Registration:
Approval Date:
11 September 2024
ADEPT:
ADEPT1324
Patient characteristics and treatment pathways in patients with asthma or asthma-COPD overlap treated with Medium-Strength ICS/LABA and switching to High-StrEngth ICS/LABA or Medium-Strength TRImbow (BETRI).
Organisation:
Observational and Pragmatic Research (OPRI)
Study Registration:
Approval Date:
12 June 2024
ADEPT:
ADEPT0824
Repurposing Existing Pharmaceuticals for the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Organisation:
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Study Registration:
Approval Date:
24 July 2024
ADEPT:
ADEPT0924
Disease trajectory and treatment escalation in severe asthma: A retrospective analysis of data from the Optimum Patient Care Research Database (OPCRD).
Organisation:
Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University
Study Registration:
Approval Date:
9 September 2024
ADEPT:
ADEPT1224
Evaluation of patient histories completeness in linked primary and secondary care electronic health records (EHR) data – a proof of concept study between Akrivia Health and OPCRD.
Organisation:
Optimum Patient Care
Study Registration:
Approval Date:
13 November 2024
ADEPT:
ADEPT1624
Validity of using prescription records to identify patient comorbidities.
Organisation:
Queens University Belfast
Study Registration:
Approval Date:
15 November 2024
ADEPT:
ADEPT1824
Anticoagulants, diabetes and reflux – associations with new diagnoses, and subsequent natural history, of idiopathic pulmonary fibrosis and other interstitial lung diseases: Analyses using the Optimum Patient Care Research Database (OPCRD)
Organisation:
University of Sydney
Study Registration:
Approval Date:
26 September 2023
ADEPT:
ADEPT0723
Selection of Eligible People for Lung Cancer Screening Using Electronic Primary Care Data: Development of new risk prediction models.
Organisation:
Cancer Research UK
Study Registration:
Approval Date:
18 July 2023
ADEPT:
ADEPT0423
Comparison of prescription, laboratory recording and recording of death in two UK primary care databases – a cohort study using CPRD Aurum and OPCRD databases.
Organisation:
Optimum Patient Care
Study Registration:
Approval Date:
13 July 2023
ADEPT:
ADEPT0323
Redefining severe asthma to high-risk asthma: Analysis of real-world data ot investigate patients who are at high risk of exacerbations, worsening of symptoms, and a loss of asthma control over time.
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
24 July 2023
ADEPT:
ADEPT0523
AFLOAT: Predicting the risk of Advanced non-alcoholic Fatty Liver Disease in cOmmunity patients with Abnormal Transaminases
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
29 June 2022
ADEPT:
ADEPT0522
Using Electronic Health Records (EHR) for the development of Personalised Hormonal Therapy
Organisation:
Aveta Life
Study Registration:
Approval Date:
26 July 2022
ADEPT:
ADEPT0622
Development and evaluation of clinical prediction models to estimate the risk of midgut
neuroendocrine tumours using statistical and machine learning approaches: an exploratory
study
Organisation:
Mendelian Health
Study Registration:
Approval Date:
5 September 2022
ADEPT:
ADEPT0822
A matched case control study to identify features associated with a group of rare diseases and examine the case identification accuracy of MendelScan, a rare disease case finding tool.
Organisation:
Mendelian Health
Study Registration:
Approval Date:
26 September 2021
ADEPT:
ADEPT1221
Data Resource Profile: Optimum Patient Care Research Database (OPCRD)
Organisation:
Optimum Patient Care Global Limited (OPCG), Momentum Data
Study Registration:
Approval Date:
15 February 2021
ADEPT:
ADEPT0121
Gallbladder pathology as an early sign of metachromatic leukodystrophy an exploratory study using electronic health records
Organisation:
Mendelian Health
Study Registration:
Approval Date:
9 December 2021
ADEPT:
ADEPT1821
An exploratory study on epidemiological and genetic testing trends for retinitis pigmentosa and leber congenital amaurosis using primary care electronic records.
Organisation:
Mendelian Health
Study Registration:
Approval Date:
27 December 2021
ADEPT:
ADEPT1923
Deriving asthma subtypes from electronic health records using statistical learning
Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
16 August 2021
ADEPT:
ADEPT0619
The incidence of psychological comorbidities in paediatric and young adults with inflammatory bowel disease, and the impacts of mental health conditions on quality of life, disease severity and resource utilisation: a population-based cohort study in the UK
Organisation:
Momentum Data
Study Registration:
Approval Date:
27 December 2021
ADEPT:
ADEPT1922
A retrospective observational study on characteristics, treatment patterns, and healthcare resource use of patients with xerostomia in primary care settings using Optimum Patient Care Research Database in United Kingdom
Organisation:
OPEN Health
Study Registration:
Approval Date:
9 December 2021
ADEPT:
ADEPT1921
PRagmatic EVAluation of a quality Improvement programme for people living with modifiable high-risk COPD (PREVAIL)
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
20 September 2021
ADEPT:
ADEPT1321
Patient characteristics, treatment patterns, clinical outcomes, and health care resource utilization in severe asthma subgroups: A retrospective analysis of the International Severe Asthma Registry
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
14 July 2021
ADEPT:
ADEPT0821
Unexplored associations with inflammatory skin conditions: a population-based cohort study of the risk of skin cancer, venous thromboembolism, and mental health conditions in atopic dermatitis and vitiligo
Organisation:
Momentum Data
Study Registration:
Approval Date:
14 July 2021
ADEPT:
ADEPT0721
The comparative effectiveness across severe asthma biologic classes (Anti-IL5 versus Anti-IgE) in patients eligible for both therapies
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
26 July 2020
ADEPT:
ADEPT0920
Asthma epidemiology, prevalence of asthma modifiable factors and healthcare utilisation due to asthma in England, Scotland, Wales, Northern Ireland and the UK
Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
21 July 2020
ADEPT:
ADEPT0620
Impact of Covid-19 using Platform C19: Describing a cohort of real-life patients during the Covid-19 pandemic and assessing the impact of Covid-19 and related behaviour on chronic conditions, and the effect of chronic conditions on Covid-19 outcomes.
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
18 November 2020
ADEPT:
ADEPT1720
An observational evaluation of prescribing and safety of Glycopyrronium bromide for symptomatic treatment of severe sialorrhoea (drooling) in children with chronic neurological disorders
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
21 July 2020
ADEPT:
ADEPT0720
Development of a prediction model to identify Pompe disease and Fabry disease, based on UK primary care electronic health records
Organisation:
OPEN Health
Study Registration:
Approval Date:
29 September 2020
ADEPT:
ADEPT1320
External validation of a clinical prediction model for the diagnosis of asthma in primary care
Organisation:
Usher Institute, University of Edinburgh
Study Registration:
Approval Date:
3 February 2020
ADEPT:
ADEPT0320
Impact of COVID-19 on asthma exacerbations: protocol for a cohort study in primary care
Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
16 August 2020
ADEPT:
ADEPT1020a
An observational cohort study to describe intermittent OCS utilisation and its association with adverse outcomes and healthcare resource use and costs in asthma using the OPCRD and CPRD databases.
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
29 September 2020
ADEPT:
ADEPT1120
Impact of Initiating Biologics in Patients Receiving Long-term OCS or Frequent Rescue Steroids versus Those Not Receiving Biologics
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
16 June 2020
ADEPT:
ADEPT0420
The Impact of Exacerbation Burden on Lung Function Trajectory in a Broad Asthma Population and Severe Asthma Population
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
30 July 2019
ADEPT:
ADEPT1319
Effectiveness of Dymista in asthma patients with rhinitis
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
8 April 2019
ADEPT:
ADEPT0519
IMP2ART Cluster Randomised Trial with a Nested Process Evaluation
Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
12 August 2019
ADEPT:
ADEPT1619
A study on the Prescription Patterns of Short Acting Beta-2 Agonist (SABA) and its potential effects on asthma control: A Cross-Sectional Study on SABA use in Asthma
Organisation:
Optimum Patient Care Australia
Study Registration:
Approval Date:
1 October 2019
ADEPT:
ADEPT1819
Severe Asthma in Primary Care vs. ISAR Cohort
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
14 March 2019
ADEPT:
ADEPT0319
Development of a prognostic tool using machine learning for asthma exacerbations in adolescents and adults in a retrospective cohort in primary care
Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
11 July 2019
ADEPT:
ADEPT0919
Burden of cough in UK primary care
Organisation:
Respiratory Effectiveness Group (REG)
Study Registration:
Approval Date:
7 January 2019
ADEPT:
ADEPT0119
Evaluation of patient characteristics, care pathways, prescribing patterns and costs across cancer types.
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
18 June 2019
ADEPT:
ADEPT0819
Longitudinal systemic corticosteroid utilization in the UK, 1990-2018 - An observational historical cohort study to describe the changes over time in drug utilization of systemic corticosteroids in 28 conditions in the OPCRD database.
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
13 August 2019
ADEPT:
ADEPT1719
Treatment pathways, healthcare resource utilization and associated costs in patients with ulcerative colitis
Organisation:
PH Associates
Study Registration:
Approval Date:
6 February 2019
ADEPT:
ADEPT0219
A pragmatic, cluster randomized trial evaluating the impact of an enhanced adherence package (dual bronchodilator+add-on+app) on time to treatment failure and other clinical outcomes in exacerbating COPD patients with poor adherence to mono or dual therapy over one year
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
2 May 2019
ADEPT:
ADEPT0719
Biologics in severe asthma: utilisation patterns, causes for discontinuation and switches
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
29 July 2019
ADEPT:
ADEPT1119
METNA RA Study
Organisation:
Observational & Pragmatic Research Institute (OPRI), OPEN Health
Study Registration:
Approval Date:
8 July 2018
ADEPT:
ADEPT0518
OPRI-1808: Dementia at Sea: a prevalence study in the United Kingdom
Organisation:
University of Plymouth, Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
30 September 2018
ADEPT:
ADEPT1318
British Lung Foundation (BLF) Asthma Management Project
Organisation:
Observational & Pragmatic Research Institute (OPRI), British Lung Foundation
Study Registration:
Approval Date:
7 May 2018
ADEPT:
ADEPT1018
Validation of the new GOLD 2017 classification scheme among patients with Chronic Obstructive Pulmonary Disease
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
31 October 2018
ADEPT:
ADEPT0918
An observational evaluation of the off-label prescribing and safety of glycopyrronium bromide (GLY) for symptomatic treatment of severe sialorrhoea (drooling) and/or hyperhidrosis (excessive sweating)
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
2 September 2018
ADEPT:
ADEPT1118
Demographic and Clinical Characteristics of Severe Asthma Patients Worldwide
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
4 September 2018
ADEPT:
ADEPT1218
International Sever Asthma Registry (ISAR)
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
22 April 2018
ADEPT:
ADEPT0218
OPC Questionnaire Item Reduction: An exploratory study with the aim of reducing item numbers while the shorter version continues to be predictive of future exacerbations