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Approved Studies

Studies requesting data from the OPC Research Database must undergo protocol approval via ADEPT before any data access is granted. ADEPT is an independent body of experts who ensure the database is only utilised as part of projects that adhere to high standards of confidentiality, scientific rigour, and ethical integrity.

 

Below is an index of protocols approved to use the OPCRD. Filter by year in the right-hand column and click on protocols for further information (coming soon).

 

Following publication, peer-reviewed articles using OPCRD data are listed on our publications page.  

The UVAC study: Understanding Variation in Admissions from Care Homes.

Organisation:
National Institute for Health and Care Research (NIHR) Academy
Study Registration:
Approval Date:
29 January 2025
ADEPT:
ADEPT0325

SGLT2 inhibitor utilisation in adults with chronic kidney disease, type 2 diabetes mellitus and chronic heart failure in the UK.

Organisation:
Lane Clark and Peacock
Study Registration:
Approval Date:
20 January 2025
ADEPT:
ADEPT0125

Incidence, prevalence, and characterisation of medicines with suggested drug shortages in Europe (EHDEN MEGA Study).

Organisation:
Optimum Patient Care
Study Registration:
Approval Date:
24 April 2024
ADEPT:
ADEPT0624

The development and evaluation of prognostic models to predict biologic eligibility.

Organisation:
Queen’s University Belfast
Study Registration:
Approval Date:
28 October 2024
ADEPT:
ADEPT1524

Investigating the effectiveness of interventions that improve medication adherence in school-aged children with asthma.

Organisation:
University of Sheffield
Study Registration:
Approval Date:
19 April 2024
ADEPT:
ADEPT0524

CompAIR: COMParative clinical effectiveness of FostAIR (extrafine beclomethasone/formoterol) as maintenance and reliever therapies in adult patients with asthma.

Organisation:
Observational and Pragmatic Research (OPRI)
Study Registration:
Approval Date:
15 November 2024
ADEPT:
ADEPT1724

Phenotyping Asthma Exacerbations in primary care: an electronic medical record study (PHASE).

Organisation:
University of Oxford
Study Registration:
Approval Date:
5 December 2024
ADEPT:
ADEPT2024

Development of a prediction model to identify Neuroendocrine tumours (NET), based on UK electronic primary healthcare records.

Organisation:
Volv Global SA
Study Registration:
Approval Date:
11 September 2024
ADEPT:
ADEPT1324

Depicting real-life treatment journeys for patients affected with an immune-inflammatory condition and treated with methotrexate.

Organisation:
Scienta Lab
Study Registration:
Approval Date:
16 May 2024
ADEPT:
ADEPT0724

Patient characteristics and treatment pathways in patients with asthma or asthma-COPD overlap treated with Medium-Strength ICS/LABA and switching to High-StrEngth ICS/LABA or Medium-Strength TRImbow (BETRI).

Organisation:
Observational and Pragmatic Research (OPRI)
Study Registration:
Approval Date:
12 June 2024
ADEPT:
ADEPT0824

The Breathlessness Rapid Evaluation and Therapy Study - CDSS Development.

Organisation:
The George Institute for Global Health
Study Registration:
Approval Date:
26 January 2024
ADEPT:
ADEPT0224

AI-powered stratification of autoimmune diseases for Precision Medicine.

Organisation:
Scienta Lab
Study Registration:
Approval Date:
10 January 2024
ADEPT:
ADEPT0124

Repurposing Existing Pharmaceuticals for the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Organisation:
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Study Registration:
Approval Date:
24 July 2024
ADEPT:
ADEPT0924

Disease trajectory and treatment escalation in severe asthma: A retrospective analysis of data from the Optimum Patient Care Research Database (OPCRD).

Organisation:
Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University
Study Registration:
Approval Date:
9 September 2024
ADEPT:
ADEPT1224

Evaluation of patient histories completeness in linked primary and secondary care electronic health records (EHR) data – a proof of concept study between Akrivia Health and OPCRD.

Organisation:
Optimum Patient Care
Study Registration:
Approval Date:
13 November 2024
ADEPT:
ADEPT1624

Validity of using prescription records to identify patient comorbidities.

Organisation:
Queens University Belfast
Study Registration:
Approval Date:
15 November 2024
ADEPT:
ADEPT1824

Real-world use of Breztri/Trixeo for the management of COPD in a UK primary care population.

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
30 March 2023
ADEPT:
ADEPT0123

Anticoagulants, diabetes and reflux – associations with new diagnoses, and subsequent natural history, of idiopathic pulmonary fibrosis and other interstitial lung diseases: Analyses using the Optimum Patient Care Research Database (OPCRD)

Organisation:
University of Sydney
Study Registration:
Approval Date:
26 September 2023
ADEPT:
ADEPT0723

Selection of Eligible People for Lung Cancer Screening Using Electronic Primary Care Data: Development of new risk prediction models.

Organisation:
Cancer Research UK
Study Registration:
Approval Date:
18 July 2023
ADEPT:
ADEPT0423

Patient characteristics and treatment pathways in patients with COPD initiated on ICS/LABA/LAMA and LABA/LAMA treatment.

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
5 September 2023
ADEPT:
ADEPT0623

Characterising Patient Pathways to the Diagnosis of Interstitial Lung Disease: Real World Data Study.

Organisation:
University of Sydney
Study Registration:
Approval Date:
26 September 2023
ADEPT:
ADEPT0823

Comparison of prescription, laboratory recording and recording of death in two UK primary care databases – a cohort study using CPRD Aurum and OPCRD databases.

Organisation:
Optimum Patient Care
Study Registration:
Approval Date:
13 July 2023
ADEPT:
ADEPT0323

Cardiopulmonary risk model for patients with chronic obstructive pulmonary disease.

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
16 May 2023
ADEPT:
ADEPT0223

Redefining severe asthma to high-risk asthma: Analysis of real-world data ot investigate patients who are at high risk of exacerbations, worsening of symptoms, and a loss of asthma control over time.

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
24 July 2023
ADEPT:
ADEPT0523

Impact of biologic initiation on steroid burden and new-onset of potentially related OCS related risks in patients with severe asthma (SOLAR).

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
13 January 2023
ADEPT:
ADEPT1422

High Risk COPD: Understanding high-risk COPD: Analysis of real-world data to investigate characteristics and outcomes in patients with high-risk COPD.

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
27 October 2023
ADEPT:
ADEPT0923

A retrospective observational study on effectiveness of influenza vaccine Supemtek compared to other vaccines in adults aged 18 years and above in the United Kingdom a feasibility study.

Organisation:
OPEN Health
Study Registration:
Approval Date:
3 January 2023
ADEPT:
ADEPT 1322

AFLOAT: Predicting the risk of Advanced non-alcoholic Fatty Liver Disease in cOmmunity patients with Abnormal Transaminases

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
29 June 2022
ADEPT:
ADEPT0522

Using Electronic Health Records (EHR) for the development of Personalised Hormonal Therapy

Organisation:
Aveta Life
Study Registration:
Approval Date:
26 July 2022
ADEPT:
ADEPT0622

Determining the prevalence of severe asthma in children in UK primary care

Organisation:
Respiratory Effectiveness Group (REG)
Study Registration:
Approval Date:
22 October 2022
ADEPT:
ADEPT1122

Drug utilisation and incident rates of adverse events in children with sialorrhoea who are treated with glycopyrronium

Organisation:
University of East Anglia (UEA)
Study Registration:
Approval Date:
6 June 2022
ADEPT:
ADEPT1925

Characteristics, Treatment and Healthcare Resource Utilisation in Patients Diagnosed with Neuropathic or Chronic Pain Using Primary Care Electronic Health Records in the United Kingdom

Organisation:
OPEN Health
Study Registration:
Approval Date:
4 July 2022
ADEPT:
ADEPT0322

Development and evaluation of clinical prediction models to estimate the risk of midgut
neuroendocrine tumours using statistical and machine learning approaches: an exploratory
study

Organisation:
Mendelian Health
Study Registration:
Approval Date:
5 September 2022
ADEPT:
ADEPT0822

Exploring differences in asthma disease severity and pathways: variation by ethnicity and socioeconomic status

Organisation:
Queens University Belfast
Study Registration:
Approval Date:
17 August 2021
ADEPT:
ADEPT0120

Clinical outcomes before and after biologic treatment by biologic class, by individual biologic, and by subgroups of baseline characteristics (LUMINANT)

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
3 October 2021
ADEPT:
ADEPT1421

Patterns of Management of high-risk COPD in Primary Care, and Opportunities for optimising treatment in the United Kingdom 2000- 2019: Study Protocol

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
17 February 2021
ADEPT:
ADEPT0221

A matched case control study to identify features associated with a group of rare diseases and examine the case identification accuracy of MendelScan, a rare disease case finding tool.

Organisation:
Mendelian Health
Study Registration:
Approval Date:
26 September 2021
ADEPT:
ADEPT1221

Expert opinion on the impact of inhaler choice on climate change and personalised healthcare

Organisation:
Respiratory Effectiveness Group (REG)
Study Registration:
Approval Date:
17 February 2021
ADEPT:
ADEPT0321

PhEnotypic Characteristics, coMorBidities and response to thErapeutic inteRventions associated with non-type 2 asthma (EMBER)

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
3 November 2021
ADEPT:
ADEPT1521

Development of a predictive model algorithm to identify patients with hypophosphatasia, using Optimum Patient Care Record Database in United Kingdom

Organisation:
OPEN Health
Study Registration:
Approval Date:
15 November 2021
ADEPT:
ADEPT1721

Data Resource Profile: Optimum Patient Care Research Database (OPCRD)

Organisation:
Optimum Patient Care Global Limited (OPCG), Momentum Data
Study Registration:
Approval Date:
15 February 2021
ADEPT:
ADEPT0121

Gallbladder pathology as an early sign of metachromatic leukodystrophy an exploratory study using electronic health records

Organisation:
Mendelian Health
Study Registration:
Approval Date:
9 December 2021
ADEPT:
ADEPT1821

EffectIveness of bioloGics (by classes) in patieNts with dIfferent combination of T2 biomarkErs (IGNITE)

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
8 November 2021
ADEPT:
ADEPT1621

An exploratory study on epidemiological and genetic testing trends for retinitis pigmentosa and leber congenital amaurosis using primary care electronic records.

Organisation:
Mendelian Health
Study Registration:
Approval Date:
27 December 2021
ADEPT:
ADEPT1923

Deriving asthma subtypes from electronic health records using statistical learning

Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
16 August 2021
ADEPT:
ADEPT0619

Biologic usage patterns, clinical outcomes and healthcare utilization (CLEAR)

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
12 September 2021
ADEPT:
ADEPT1021

The incidence of psychological comorbidities in paediatric and young adults with inflammatory bowel disease, and the impacts of mental health conditions on quality of life, disease severity and resource utilisation: a population-based cohort study in the UK

Organisation:
Momentum Data
Study Registration:
Approval Date:
27 December 2021
ADEPT:
ADEPT1922

ImPact of comoRbidity In Severe asthMa patients (PRISM)

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
15 September 2021
ADEPT:
ADEPT1121

A retrospective observational study on characteristics, treatment patterns, and healthcare resource use of patients with xerostomia in primary care settings using Optimum Patient Care Research Database in United Kingdom

Organisation:
OPEN Health
Study Registration:
Approval Date:
9 December 2021
ADEPT:
ADEPT1921

PRagmatic EVAluation of a quality Improvement programme for people living with modifiable high-risk COPD (PREVAIL)

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
20 September 2021
ADEPT:
ADEPT1321

Patient characteristics, treatment patterns, clinical outcomes, and health care resource utilization in severe asthma subgroups: A retrospective analysis of the International Severe Asthma Registry

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
14 July 2021
ADEPT:
ADEPT0821

The prevalence of comorbidities in COPD patients, and their impact on health status and COPD symptoms in primary care patients: an UNLOCK study from the IPCRG

Organisation:
International Primary Care Respiratory Group (IPCRG)
Study Registration:
Approval Date:
20 June 2021
ADEPT:
ADEPT0621

Unexplored associations with inflammatory skin conditions: a population-based cohort study of the risk of skin cancer, venous thromboembolism, and mental health conditions in atopic dermatitis and vitiligo

Organisation:
Momentum Data
Study Registration:
Approval Date:
14 July 2021
ADEPT:
ADEPT0721

Comparative safety of extrafine beclometasone fixed dose combinations (FDC) and fluticasone FDC in COPD

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
26 July 2020
ADEPT:
ADEPT0820

The comparative effectiveness across severe asthma biologic classes (Anti-IL5 versus Anti-IgE) in patients eligible for both therapies

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
26 July 2020
ADEPT:
ADEPT0920

Asthma epidemiology, prevalence of asthma modifiable factors and healthcare utilisation due to asthma in England, Scotland, Wales, Northern Ireland and the UK

Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
21 July 2020
ADEPT:
ADEPT0620

Severe Asthma Super-Responders Delphi Exercise

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
3 February 2020
ADEPT:
ADEPT0220

Impact of Covid-19 using Platform C19: Describing a cohort of real-life patients during the Covid-19 pandemic and assessing the impact of Covid-19 and related behaviour on chronic conditions, and the effect of chronic conditions on Covid-19 outcomes.

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
18 November 2020
ADEPT:
ADEPT1720

An observational evaluation of prescribing and safety of Glycopyrronium bromide for symptomatic treatment of severe sialorrhoea (drooling) in children with chronic neurological disorders

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
21 July 2020
ADEPT:
ADEPT0720

Development of a prediction model to identify Pompe disease and Fabry disease, based on UK primary care electronic health records

Organisation:
OPEN Health
Study Registration:
Approval Date:
29 September 2020
ADEPT:
ADEPT1320

Defining and Characterising Responders To Biologic TrEAtment In Severe AsthMa Patients (BEAM)

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
29 September 2020
ADEPT:
ADEPT1220

External validation of a clinical prediction model for the diagnosis of asthma in primary care

Organisation:
Usher Institute, University of Edinburgh
Study Registration:
Approval Date:
3 February 2020
ADEPT:
ADEPT0320

Impact of COVID-19 on asthma exacerbations: protocol for a cohort study in primary care

Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
16 August 2020
ADEPT:
ADEPT1020a

An observational cohort study to describe intermittent OCS utilisation and its association with adverse outcomes and healthcare resource use and costs in asthma using the OPCRD and CPRD databases.

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
29 September 2020
ADEPT:
ADEPT1120

Impact of Initiating Biologics in Patients Receiving Long-term OCS or Frequent Rescue Steroids versus Those Not Receiving Biologics

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
16 June 2020
ADEPT:
ADEPT0420

The Impact of Exacerbation Burden on Lung Function Trajectory in a Broad Asthma Population and Severe Asthma Population

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
30 July 2019
ADEPT:
ADEPT1319

Addition of antibiotics to usual care management of asthma exacerbations: a real-life comparative effectiveness study

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
20 January 2016
ADEPT:
ADEPT1519

Effectiveness of Dymista in asthma patients with rhinitis

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
8 April 2019
ADEPT:
ADEPT0519

Effectiveness of Fostair (ICS/LABA) vs. dual bronchodilation (LABA/LAMA) in COPD (FELICITI Study)

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
2 April 2019
ADEPT:
ADEPT0419

IMP2ART Cluster Randomised Trial with a Nested Process Evaluation

Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
12 August 2019
ADEPT:
ADEPT1619

A study on the Prescription Patterns of Short Acting Beta-2 Agonist (SABA) and its potential effects on asthma control: A Cross-Sectional Study on SABA use in Asthma

Organisation:
Optimum Patient Care Australia
Study Registration:
Approval Date:
1 October 2019
ADEPT:
ADEPT1819

Severe Asthma in Primary Care vs. ISAR Cohort

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
14 March 2019
ADEPT:
ADEPT0319

Development of a prognostic tool using machine learning for asthma exacerbations in adolescents and adults in a retrospective cohort in primary care

Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
11 July 2019
ADEPT:
ADEPT0919

Onset of asthma in severe asthma patients

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
29 July 2019
ADEPT:
ADEPT1219

Eosinophilic asthma phenotypes and associated clinical outcomes

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
21 October 2019
ADEPT:
ADEPT1919

Biomarker Relatability in the International Severe Asthma Registry (BRISAR)

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
23 July 2019
ADEPT:
ADEPT1019

Burden of cough in UK primary care

Organisation:
Respiratory Effectiveness Group (REG)
Study Registration:
Approval Date:
7 January 2019
ADEPT:
ADEPT0119

Evaluation of patient characteristics, care pathways, prescribing patterns and costs across cancer types.

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
18 June 2019
ADEPT:
ADEPT0819

Longitudinal systemic corticosteroid utilization in the UK, 1990-2018 - An observational historical cohort study to describe the changes over time in drug utilization of systemic corticosteroids in 28 conditions in the OPCRD database.

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
13 August 2019
ADEPT:
ADEPT1719

Treatment pathways, healthcare resource utilization and associated costs in patients with ulcerative colitis

Organisation:
PH Associates
Study Registration:
Approval Date:
6 February 2019
ADEPT:
ADEPT0219

A pragmatic, cluster randomized trial evaluating the impact of an enhanced adherence package (dual bronchodilator+add-on+app) on time to treatment failure and other clinical outcomes in exacerbating COPD patients with poor adherence to mono or dual therapy over one year

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
2 May 2019
ADEPT:
ADEPT0719

Biologics in severe asthma: utilisation patterns, causes for discontinuation and switches

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
29 July 2019
ADEPT:
ADEPT1119

Implications of ICS withdrawal in the real-life management of COPD

Organisation:
Respiratory Effectiveness Group (REG)
Study Registration:
Approval Date:
6 August 2019
ADEPT:
ADEPT1419

METNA RA Study

Organisation:
Observational & Pragmatic Research Institute (OPRI), OPEN Health
Study Registration:
Approval Date:
8 July 2018
ADEPT:
ADEPT0518

The Characterisation and Comparison of Eosinophilic and Non-eosinophilic Phenotypes of Severe Asthma

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
18 December 2018
ADEPT:
ADEPT1418

OPRI-1808: Dementia at Sea: a prevalence study in the United Kingdom

Organisation:
University of Plymouth, Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
30 September 2018
ADEPT:
ADEPT1318

British Lung Foundation (BLF) Asthma Management Project

Organisation:
Observational & Pragmatic Research Institute (OPRI), British Lung Foundation
Study Registration:
Approval Date:
7 May 2018
ADEPT:
ADEPT1018

Validation of the new GOLD 2017 classification scheme among patients with Chronic Obstructive Pulmonary Disease

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
31 October 2018
ADEPT:
ADEPT0918

An observational evaluation of the off-label prescribing and safety of glycopyrronium bromide (GLY) for symptomatic treatment of severe sialorrhoea (drooling) and/or hyperhidrosis (excessive sweating)

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
2 September 2018
ADEPT:
ADEPT1118

Demographic and Clinical Characteristics of Severe Asthma Patients Worldwide

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
4 September 2018
ADEPT:
ADEPT1218

Use of degarelix among patients with prostate cancer in daily practice

Organisation:
Observational & Pragmatic Research Institute (OPRI), OPEN Health
Study Registration:
Approval Date:
ADEPT:
ADEPT0618

International Sever Asthma Registry (ISAR)

Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
22 April 2018
ADEPT:
ADEPT0218

Real-life Characterisation of Patients with Active Asthma and Type 2 Asthma Comorbidities

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
23 April 2018
ADEPT:
ADEPT0318

OPC Questionnaire Item Reduction: An exploratory study with the aim of reducing item numbers while the shorter version continues to be predictive of future exacerbations

Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
10 June 2018
ADEPT:
ADEPT0418

ASSIST: A clinical interventional study into Airways disease case-fInding and 'at risk' case management

Organisation:
University of Southampton
Study Registration:
Approval Date:
14 March 2018
ADEPT:
ADEPT0118
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