Approved Studies

Studies requesting data from the OPC Research Database must undergo protocol approval via ADEPT before any data access is granted. ADEPT is an independent body of experts who ensure the database is only utilised as part of projects that adhere to high standards of confidentiality, scientific rigour, and ethical integrity.

Below is an index of protocols approved to use the OPCRD. Filter by year in the right-hand column and click on protocols for further information (coming soon).

Following publication, peer-reviewed articles using OPCRD data are listed on our publications page.

SGLT2 inhibitor utilisation in adults with chronic kidney disease, type 2 diabetes mellitus and chronic heart failure in the UK.

Organisation:

Lane Clark and Peacock

Study Registration:

ENCePP EUPAS23376

Approval Date:

20 January 2025

ADEPT:

ADEPT0125

The real world impact of Glucagon-like peptide 1 receptor agonists on asthma control in people with obesity and high-risk asthma

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

ADEPT:

ADEPT0523

The UVAC study: Understanding Variation in Admissions from Care Homes.

Organisation:

National Institute for Health and Care Research (NIHR) Academy

Study Registration:

Approval Date:

29 January 2025

ADEPT:

ADEPT0325

Predicting risk of morbidities associated with oral corticosteroid prescription for asthma

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

EUPAS1000000336

Approval Date:

ADEPT:

ADEPT1120

Incidence and survival of interstitial lung diseases in the UK in 2010–2019

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

ADEPT:

ADEPT PROTOCOL2332

Investigating the effectiveness of interventions that improve medication adherence in school-aged children with asthma.

Organisation:

University of Sheffield

Study Registration:

Approval Date:

19 April 2024

ADEPT:

ADEPT0524

Development of a prediction model to identify Neuroendocrine tumours (NET), based on UK electronic primary healthcare records.

Organisation:

Volv Global SA

Study Registration:

Approval Date:

11 September 2024

ADEPT:

ADEPT1324

Budesonide/glycopyrrolate/formoterol for the management of COPD in a UK primary care population: real-world use and early medication success

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

EUPAS104156

Approval Date:

ADEPT:

ADEPT0123

Exacerbation history and blood eosinophil count prior to diagnosis of COPD and risk of subsequent exacerbations

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

EUPAS107087

Approval Date:

ADEPT:

ADEPT0923

Depicting real-life treatment journeys for patients affected with an immune-inflammatory condition and treated with methotrexate.

Organisation:

Scienta Lab

Study Registration:

ENCePP EUPAS1000000159

Approval Date:

16 May 2024

ADEPT:

ADEPT0724

Incidence, prevalence, and characterisation of medicines with suggested drug shortages in Europe (EHDEN MEGA Study).

Organisation:

Optimum Patient Care

Study Registration:

ENCePP EUPAS106954

Approval Date:

24 April 2024

ADEPT:

ADEPT0624

Validity of using prescription records to identify patient comorbidities.

Organisation:

Queens University Belfast

Study Registration:

ENCePP EUPAS1000000359

Approval Date:

15 November 2024

ADEPT:

ADEPT1824

Evaluation of patient histories completeness in linked primary and secondary care electronic health records (EHR) data – a proof of concept study between Akrivia Health and OPCRD.

Organisation:

Optimum Patient Care

Study Registration:

Approval Date:

13 November 2024

ADEPT:

ADEPT1624

The Breathlessness Rapid Evaluation and Therapy Study - CDSS Development.

Organisation:

The George Institute for Global Health

Study Registration:

ENCePP EUPAS1000000018

Approval Date:

26 January 2024

ADEPT:

ADEPT0224

Longitudinal patterns of intermittent oral corticosteroid use for asthma in the UK

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCEPP EUPAS37065

Approval Date:

ADEPT:

ADEPT1120
ISAC_20_000071

Patient characteristics and treatment pathways in patients with asthma or asthma-COPD overlap treated with Medium-Strength ICS/LABA and switching to High-StrEngth ICS/LABA or Medium-Strength TRImbow (BETRI).

Organisation:

Observational and Pragmatic Research (OPRI)

Study Registration:

ENCePP EUPAS1000000205

Approval Date:

12 June 2024

ADEPT:

ADEPT0824

CompAIR: COMParative clinical effectiveness of FostAIR (extrafine beclomethasone/formoterol) as maintenance and reliever therapies in adult patients with asthma.

Organisation:

Observational and Pragmatic Research (OPRI)

Study Registration:

ENCePP EUPAS1000000377

Approval Date:

15 November 2024

ADEPT:

ADEPT1724

Risk of pneumonia in patients with COPD initiating fixed dose inhaled corticosteroid (ICS) / long-acting bronchodilator (LABD) formulations containing extrafine beclometasone dipropionate versus patients initiating LABD without ICS

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS35439

Approval Date:

ADEPT:

ADEPT0821

Phenotyping Asthma Exacerbations in primary care: an electronic medical record study (PHASE).

Organisation:

University of Oxford

Study Registration:

Approval Date:

5 December 2024

ADEPT:

ADEPT2024

The development and evaluation of prognostic models to predict biologic eligibility.

Organisation:

Queen’s University Belfast

Study Registration:

ENCePP EUPAS1000000359

Approval Date:

28 October 2024

ADEPT:

ADEPT1524

Trends in systemic glucocorticoid utilisation in the United Kingdom from 1990 to 2019: a population-based, serial cross-sectional analysis

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

EUPAS30943

Approval Date:

ADEPT:

ADEPT1719

Disease trajectory and treatment escalation in severe asthma: A retrospective analysis of data from the Optimum Patient Care Research Database (OPCRD).

Organisation:

Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University

Study Registration:

ENCePP EUPAS1000000292

Approval Date:

9 September 2024

ADEPT:

ADEPT1224

Repurposing Existing Pharmaceuticals for the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Organisation:

Shandong Provincial Hospital Affiliated to Shandong First Medical University

Study Registration:

Approval Date:

24 July 2024

ADEPT:

ADEPT0924

AI-powered stratification of autoimmune diseases for Precision Medicine.

Organisation:

Scienta Lab

Study Registration:

ENCePP EUPAS107902

Approval Date:

10 January 2024

ADEPT:

ADEPT0124

Real-world use of Breztri/Trixeo for the management of COPD in a UK primary care population.

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS104156

Approval Date:

30 March 2023

ADEPT:

ADEPT0123

Data Resource Profile: Optimum Patient Care Research Database (OPCRD)

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

ADEPT:

20/EM/0148

Impact of biologic initiation on steroid burden and new-onset of potentially related OCS related risks in patients with severe asthma (SOLAR).

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS104139

Approval Date:

13 January 2023

ADEPT:

ADEPT1422

Comparison of prescription, laboratory recording and recording of death in two UK primary care databases – a cohort study using CPRD Aurum and OPCRD databases.

Organisation:

Optimum Patient Care

Study Registration:

Approval Date:

13 July 2023

ADEPT:

ADEPT0323

Application of an algorithm to analyse patterns of intermittent oral corticosteroid use in asthma

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

ADEPT:

ADEPT1120
ISAC 20_000071

Selection of Eligible People for Lung Cancer Screening Using Electronic Primary Care Data: Development of new risk prediction models.

Organisation:

Cancer Research UK

Study Registration:

Approval Date:

18 July 2023

ADEPT:

ADEPT0423

Anticoagulants, diabetes and reflux – associations with new diagnoses, and subsequent natural history, of idiopathic pulmonary fibrosis and other interstitial lung diseases: Analyses using the Optimum Patient Care Research Database (OPCRD)

Organisation:

University of Sydney

Study Registration:

Approval Date:

26 September 2023

ADEPT:

ADEPT0723

The impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care

Organisation:

UK Severe Asthma Registry

Study Registration:

Approval Date:

ADEPT:

ADEPT0120

Patient characteristics and treatment pathways in patients with COPD initiated on ICS/LABA/LAMA and LABA/LAMA treatment.

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS106491

Approval Date:

5 September 2023

ADEPT:

ADEPT0623

Cardiopulmonary risk model for patients with chronic obstructive pulmonary disease.

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS105272

Approval Date:

16 May 2023

ADEPT:

ADEPT0223

A retrospective observational study on effectiveness of influenza vaccine Supemtek compared to other vaccines in adults aged 18 years and above in the United Kingdom a feasibility study.

Organisation:

OPEN Health

Study Registration:

ENCePP EUPAS50220

Approval Date:

3 January 2023

ADEPT:

ADEPT 1322

Redefining severe asthma to high-risk asthma: Analysis of real-world data ot investigate patients who are at high risk of exacerbations, worsening of symptoms, and a loss of asthma control over time.

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS105920

Approval Date:

24 July 2023

ADEPT:

ADEPT0523

Implementation of a primary care asthma management quality improvement programme across 68 general practice sites

Organisation:

Optimum Patient Care Limited

Study Registration:

Approval Date:

ADEPT:

ADEPT1018
20/EM/0148

Characterising Patient Pathways to the Diagnosis of Interstitial Lung Disease: Real World Data Study.

Organisation:

University of Sydney

Study Registration:

ENCePP EUPAS20994

Approval Date:

26 September 2023

ADEPT:

ADEPT0823

Identification of key opportunities for optimising the management of high-risk COPD patients in the UK using the CONQUEST Quality Standards: an observational longitudinal study

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

ADEPT:

ADEPT0221

High Risk COPD: Understanding high-risk COPD: Analysis of real-world data to investigate characteristics and outcomes in patients with high-risk COPD.

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS107087

Approval Date:

27 October 2023

ADEPT:

ADEPT0923

Characteristics, Treatment and Healthcare Resource Utilisation in Patients Diagnosed with Neuropathic or Chronic Pain Using Primary Care Electronic Health Records in the United Kingdom

Organisation:

OPEN Health

Study Registration:

ENCePP EUPAS47913

Approval Date:

4 July 2022

ADEPT:

ADEPT0322

Defining clinical subtypes of adult asthma using electronic health records: analysis of a large UK primary care database with external validation

Organisation:

Asthma UK Centre for Applied Research

Study Registration:

Approval Date:

ADEPT:

ADEPT0619

Drug utilisation and incident rates of adverse events in children with sialorrhoea who are treated with glycopyrronium

Organisation:

University of East Anglia (UEA)

Study Registration:

ENCePP EUPAS48222

Approval Date:

6 June 2022

ADEPT:

ADEPT1925

Proactive risk management: A novel approach to embedding OCS stewardship into asthma care

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

ADEPT:

Development and evaluation of clinical prediction models to estimate the risk of midgut
neuroendocrine tumours using statistical and machine learning approaches: an exploratory
study

Organisation:

Mendelian Health

Study Registration:

Approval Date:

5 September 2022

ADEPT:

ADEPT0822

Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo

Organisation:

Momentum Data

Study Registration:

NCT04969419

Approval Date:

ADEPT:

ADEPT 0721

Effect of stepping up to high-dose inhaled corticosteroids in patients with asthma

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCEPP EUPAS15869

Approval Date:

ADEPT:

ADEPT2016
ISAC_16_236

An observational cohort study to describe intermittent oral corticosteroid use and its association with adverse events in asthma and An observational UK cohort study to describe intermittent oral corticosteroid prescribing patterns and their association with adverse outcomes in asthma

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS37065

Approval Date:

ADEPT:

ISAC 20_000071
ADEPT1120

Using Electronic Health Records (EHR) for the development of Personalised Hormonal Therapy

Organisation:

Aveta Life

Study Registration:

Approval Date:

26 July 2022

ADEPT:

ADEPT0622

An observational UK cohort study to describe intermittent oral corticosteroid prescribing patterns and their association with adverse outcomes in asthma

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP ENCEPP EUPAS37065

Approval Date:

ADEPT:

ADEPT1120
ISAC 20_000071

Determining the prevalence of severe asthma in children in UK primary care

Organisation:

Respiratory Effectiveness Group (REG)

Study Registration:

ENCePP EUPAS50650

Approval Date:

22 October 2022

ADEPT:

ADEPT1122

AFLOAT: Predicting the risk of Advanced non-alcoholic Fatty Liver Disease in cOmmunity patients with Abnormal Transaminases

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

29 June 2022

ADEPT:

ADEPT0522

Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health

Organisation:

Momentum Data

Study Registration:

NCT05206734

Approval Date:

ADEPT:

ADEPT 1922

The Incidence of Venous Thromboembolism in Atopic Dermatitis

Organisation:

Momentum Data

Study Registration:

NCT04969653

Approval Date:

ADEPT:

ADEPT 0721

Mental Health Associations With Vitiligo

Organisation:

Momentum Data

Study Registration:

NCT04953338

Approval Date:

ADEPT:

ADEPT 0721

Interclass Difference in Pneumonia Risk in COPD Patients Initiating Fixed Dose Inhaled Treatment Containing Extrafine Particle Beclometasone versus Fine Particle Fluticasone

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP ENCePP EUPAS35439

Approval Date:

ADEPT:

ADEPT0820

Eosinophilic and non-eosinophilic asthma: an expert consensus framework to characterize phenotypes in a global real-life severe asthma cohort

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

EUPAS31355

Approval Date:

ADEPT:

ADEPT1418

Withdrawal of inhaled corticosteroids versus continuation of triple therapy in patients with COPD in real life: Observational comparative effectiveness study

Organisation:

Respiratory Efectiveness Group

Study Registration:

ENCePP EUPAS30851

Approval Date:

ADEPT:

ADEPT1419

Characteristics of Patients in Platform 19, a COVID-19 Research Database Combining Primary Care Electronic Health Record and Patient Reported Information.

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

ADEPT:

ADEPT1720

Clinical outcomes before and after biologic treatment by biologic class, by individual biologic, and by subgroups of baseline characteristics (LUMINANT)

Organisation:

Optimum Patient Care Global Limited (OPCG)

Study Registration:

ENCePP EUPAS44027

Approval Date:

3 October 2021

ADEPT:

ADEPT1421

ImPact of comoRbidity In Severe asthMa patients (PRISM)

Organisation:

Optimum Patient Care Global Limited (OPCG)

Study Registration:

ENCePP EUPAS44024

Approval Date:

15 September 2021

ADEPT:

ADEPT1121

Asthma phenotyping in primary care: applying the International Severe Asthma Registry eosinophil phenotype algorithm across all asthma severities

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS31500

Approval Date:

ADEPT:

ADEPT1919
ISAC_19_229

Deriving asthma subtypes from electronic health records using statistical learning

Organisation:

Asthma UK Centre for Applied Research (AUKCAR)

Study Registration:

Approval Date:

16 August 2021

ADEPT:

ADEPT0619

PhEnotypic Characteristics, coMorBidities and response to thErapeutic inteRventions associated with non-type 2 asthma (EMBER)

Organisation:

Optimum Patient Care Global Limited (OPCG)

Study Registration:

ENCePP EUPAS43785

Approval Date:

3 November 2021

ADEPT:

ADEPT1521

Exploring differences in asthma disease severity and pathways: variation by ethnicity and socioeconomic status

Organisation:

Queens University Belfast

Study Registration:

ENCePP EUPAS32482

Approval Date:

17 August 2021

ADEPT:

ADEPT0120

Gallbladder pathology as an early sign of metachromatic leukodystrophy an exploratory study using electronic health records

Organisation:

Mendelian Health

Study Registration:

Approval Date:

9 December 2021

ADEPT:

ADEPT1821

Risk Predictors and Symptom Features of Long COVID Within a Broad Primary Care Patient Population Including Both Tested and Untested Patients

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

ADEPT:

ADEPT1720

A retrospective observational study on characteristics, treatment patterns, and healthcare resource use of patients with xerostomia in primary care settings using Optimum Patient Care Research Database in United Kingdom

Organisation:

OPEN Health

Study Registration:

ENCePP EUPAS44384

Approval Date:

9 December 2021

ADEPT:

ADEPT1921

PRagmatic EVAluation of a quality Improvement programme for people living with modifiable high-risk COPD (PREVAIL)

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ISRCTN ISRCTN15819828

Approval Date:

20 September 2021

ADEPT:

ADEPT1321

A matched case control study to identify features associated with a group of rare diseases and examine the case identification accuracy of MendelScan, a rare disease case finding tool.

Organisation:

Mendelian Health

Study Registration:

Approval Date:

26 September 2021

ADEPT:

ADEPT1221

Persistence of Eosinophilic Asthma Phenotype and Clinical Outcomes: A Real-world Observational Study

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS31500

Approval Date:

ADEPT:

ADEPT1919
ISAC_19_229

A real-life comparative effectiveness study into the addition of antibiotics to the management of asthma exacerbations in primary care

Organisation:

Respiratory Effectiveness Group

Study Registration:

EUPAS12132

Approval Date:

ADEPT:

ADEPT1519

Association Between a Type 2 Inflammatory Disease Burden Score and Outcomes Among Patients with Asthma

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS25203

Approval Date:

ADEPT:

ADEPT0318
ISAC_18_182R

Impact of socioeconomic status on patients with asthma: a population-based cohort study from UK primary care

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

EUPAS32482

Approval Date:

ADEPT:

ADEPT0120

Expert opinion on the impact of inhaler choice on climate change and personalised healthcare

Organisation:

Respiratory Effectiveness Group (REG)

Study Registration:

ENCePP EUPAS39494

Approval Date:

17 February 2021

ADEPT:

ADEPT0321

Persistence of eosinophilic asthma endotype and clinical outcomes: A real-world observational study

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS31500

Approval Date:

ADEPT:

ADEPT1919
ISAC19_229

Biologic usage patterns, clinical outcomes and healthcare utilization (CLEAR)

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS49548

Approval Date:

12 September 2021

ADEPT:

ADEPT1021

The prevalence of comorbidities in COPD patients, and their impact on health status and COPD symptoms in primary care patients: an UNLOCK study from the IPCRG

Organisation:

International Primary Care Respiratory Group (IPCRG)

Study Registration:

ENCePP EUPAS41519

Approval Date:

20 June 2021

ADEPT:

ADEPT0621

Data Resource Profile: Optimum Patient Care Research Database (OPCRD)

Organisation:

Optimum Patient Care Global Limited (OPCG), Momentum Data

Study Registration:

ENCePP 11192

Approval Date:

15 February 2021

ADEPT:

ADEPT0121

An exploratory study on epidemiological and genetic testing trends for retinitis pigmentosa and leber congenital amaurosis using primary care electronic records.

Organisation:

Mendelian Health

Study Registration:

Approval Date:

27 December 2021

ADEPT:

ADEPT1923

Patterns of Management of high-risk COPD in Primary Care, and Opportunities for optimising treatment in the United Kingdom 2000- 2019: Study Protocol

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS43721

Approval Date:

17 February 2021

ADEPT:

ADEPT0221

Hormone replacement therapy and risk of severe asthma exacerbation in peri-menopausal and post-menopausal women: 17-year national cohort study

Organisation:

Asthma UK Centre for Applied Research

Study Registration:

ENCePP EUPAS22967

Approval Date:

ADEPT:

ADEPT1317

Unexplored associations with inflammatory skin conditions: a population-based cohort study of the risk of skin cancer, venous thromboembolism, and mental health conditions in atopic dermatitis and vitiligo

Organisation:

Momentum Data

Study Registration:

Approval Date:

14 July 2021

ADEPT:

ADEPT0721

The incidence of psychological comorbidities in paediatric and young adults with inflammatory bowel disease, and the impacts of mental health conditions on quality of life, disease severity and resource utilisation: a population-based cohort study in the UK

Organisation:

Momentum Data

Study Registration:

Approval Date:

27 December 2021

ADEPT:

ADEPT1922

EffectIveness of bioloGics (by classes) in patieNts with dIfferent combination of T2 biomarkErs (IGNITE)

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS43806

Approval Date:

8 November 2021

ADEPT:

ADEPT1621

Patient characteristics, treatment patterns, clinical outcomes, and health care resource utilization in severe asthma subgroups: A retrospective analysis of the International Severe Asthma Registry

Organisation:

Optimum Patient Care Global Limited (OPCG)

Study Registration:

ENCePP EUPAS23651

Approval Date:

14 July 2021

ADEPT:

ADEPT0821

Maximizing Adherence and Gaining New Information For Your Chronic Obstructive Pulmonary Disease (MAGNIFY COPD): Study Protocol for the Pragmatic, Cluster Randomized Trial Evaluating the Impact of Dual Bronchodilator with Add-on Sensor and Electronic Monitoring on Clinical Outcomes

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

EUPAS31405

Approval Date:

ADEPT:

ISRCTN10567920
19/EM/0238
ADEPT0719

Development of a predictive model algorithm to identify patients with hypophosphatasia, using Optimum Patient Care Record Database in United Kingdom

Organisation:

OPEN Health

Study Registration:

ENCePP EUPAS44118

Approval Date:

15 November 2021

ADEPT:

ADEPT1721

Severe Asthma Super-Responders Delphi Exercise

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS32899

Approval Date:

3 February 2020

ADEPT:

ADEPT0220

Historical database cohort study addressing the clinical patterns prior to idiopathic pulmonary fibrosis (IPF) diagnosis in UK primary care

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCEPP EUPAS20994

Approval Date:

ADEPT:

ADEPT1517

Comparative safety of extrafine beclometasone fixed dose combinations (FDC) and fluticasone FDC in COPD

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS35439

Approval Date:

26 July 2020

ADEPT:

ADEPT0820

Hormone Replacement Therapy and Asthma Onset in Menopausal Women: National Cohort Study

Organisation:

Asthma UK and Health Data Research UK

Study Registration:

ENCePP EUPAS22967

Approval Date:

ADEPT:

ADEPT1317

A comparison of the real-life clinical effectiveness of the leading licensed ICS/LABA combination inhalers in the treatment for COPD

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCEPP EUPAS9142

Approval Date:

ADEPT:

ADEPT1016

Blood Eosinophil Count Predicts Treatment Failure and Hospital Readmission for COPD

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCEPP EUPAS16875

Approval Date:

ADEPT:

ADEPT0917
ISAC_16_297

Evaluating the Real-life Effect of MP-AzeFlu On Asthma Outcomes In Patients With Allergic Rhinitis and Asthma In UK Primary Care

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS30940

Approval Date:

ADEPT:

ADEPT0519

Predictive value of control of COPD for risk of exacerbations: An international, prospective study.

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

ENCePP EUPAS10679

Approval Date:

ADEPT:

ADEPT0115

Does use of hormonal contraceptives impact on severe exacerbation in women with asthma? A 17-year population-based cohort study

Organisation:

Asthma UK and Health Data Research UK

Study Registration:

ENCePP EUPAS22967

Approval Date:

ADEPT:

ADEPT1317

Hormonal contraceptives and onset of asthma in reproductive-age women: UK population-based cohort study

Organisation:

Asthma UK and Health Data Research UK

Study Registration:

ENCePP EUPAS22967

Approval Date:

ADEPT:

ADEPT1317

Impact of Covid-19 using Platform C19: Describing a cohort of real-life patients during the Covid-19 pandemic and assessing the impact of Covid-19 and related behaviour on chronic conditions, and the effect of chronic conditions on Covid-19 outcomes.

Organisation:

Optimum Patient Care Global Limited (OPCG)

Study Registration:

Approval Date:

18 November 2020

ADEPT:

ADEPT1720

Association between COPD exacerbations and lung function decline during maintenance therapy

Approved Studies

Organisation:

Lane Clark and Peacock

Study Registration:

Approval Date:

20 January 2025

ADEPT:

ADEPT0125

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

​

ADEPT:

ADEPT0523

Organisation:

National Institute for Health and Care Research (NIHR) Academy

Study Registration:

Approval Date:

29 January 2025

ADEPT:

ADEPT0325

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

​

ADEPT:

ADEPT1120

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

​

ADEPT:

ADEPT PROTOCOL2332

Organisation:

University of Sheffield

Study Registration:

Approval Date:

19 April 2024

ADEPT:

ADEPT0524

Organisation:

Volv Global SA

Study Registration:

Approval Date:

11 September 2024

ADEPT:

ADEPT1324

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

​

ADEPT:

ADEPT0123

Organisation:

Observational & Pragmatic Research Institute (OPRI)

Study Registration:

Approval Date:

​

ADEPT:

ADEPT0923

Organisation:

Scienta Lab

Study Registration:

Approval Date:

16 May 2024

ADEPT:

ADEPT0724

Organisation:

Optimum Patient Care

Study Registration:

Approval Date:

24 April 2024

ADEPT:

ADEPT0624

Organisation:

Queens University Belfast

ADEPT1120
ISAC_20_000071