Approved Studies
Studies requesting data from the OPC Research Database must undergo protocol approval via ADEPT before any data access is granted. ADEPT is an independent body of experts who ensure the database is only utilised as part of projects that adhere to high standards of confidentiality, scientific rigour, and ethical integrity.
Below is an index of protocols approved to use the OPCRD. Filter by year in the right-hand column and click on protocols for further information (coming soon).
Following publication, peer-reviewed articles using OPCRD data are listed on our publications page.
The real world impact of Glucagon-like peptide 1 receptor agonists on asthma control in people with obesity and high-risk asthma
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
ADEPT0523
The UVAC study: Understanding Variation in Admissions from Care Homes.
Organisation:
National Institute for Health and Care Research (NIHR) Academy
Study Registration:
Approval Date:
29 January 2025
ADEPT:
ADEPT0325
Incidence and survival of interstitial lung diseases in the UK in 2010–2019
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
ADEPT PROTOCOL2332
Investigating the effectiveness of interventions that improve medication adherence in school-aged children with asthma.
Organisation:
University of Sheffield
Study Registration:
Approval Date:
19 April 2024
ADEPT:
ADEPT0524
Development of a prediction model to identify Neuroendocrine tumours (NET), based on UK electronic primary healthcare records.
Organisation:
Volv Global SA
Study Registration:
Approval Date:
11 September 2024
ADEPT:
ADEPT1324
Evaluation of patient histories completeness in linked primary and secondary care electronic health records (EHR) data – a proof of concept study between Akrivia Health and OPCRD.
Organisation:
Optimum Patient Care
Study Registration:
Approval Date:
13 November 2024
ADEPT:
ADEPT1624
Patient characteristics and treatment pathways in patients with asthma or asthma-COPD overlap treated with Medium-Strength ICS/LABA and switching to High-StrEngth ICS/LABA or Medium-Strength TRImbow (BETRI).
Organisation:
Observational and Pragmatic Research (OPRI)
Study Registration:
Approval Date:
12 June 2024
ADEPT:
ADEPT0824
Risk of pneumonia in patients with COPD initiating fixed dose inhaled corticosteroid (ICS) / long-acting bronchodilator (LABD) formulations containing extrafine beclometasone dipropionate versus patients initiating LABD without ICS
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
ADEPT0821
Phenotyping Asthma Exacerbations in primary care: an electronic medical record study (PHASE).
Organisation:
University of Oxford
Study Registration:
Approval Date:
5 December 2024
ADEPT:
ADEPT2024
Disease trajectory and treatment escalation in severe asthma: A retrospective analysis of data from the Optimum Patient Care Research Database (OPCRD).
Organisation:
Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University
Study Registration:
Approval Date:
9 September 2024
ADEPT:
ADEPT1224
Repurposing Existing Pharmaceuticals for the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Organisation:
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Study Registration:
Approval Date:
24 July 2024
ADEPT:
ADEPT0924
Data Resource Profile: Optimum Patient Care Research Database (OPCRD)
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
20/EM/0148
Comparison of prescription, laboratory recording and recording of death in two UK primary care databases – a cohort study using CPRD Aurum and OPCRD databases.
Organisation:
Optimum Patient Care
Study Registration:
Approval Date:
13 July 2023
ADEPT:
ADEPT0323
Application of an algorithm to analyse patterns of intermittent oral corticosteroid use in asthma
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
ADEPT1120
ISAC 20_000071
Selection of Eligible People for Lung Cancer Screening Using Electronic Primary Care Data: Development of new risk prediction models.
Organisation:
Cancer Research UK
Study Registration:
Approval Date:
18 July 2023
ADEPT:
ADEPT0423
Anticoagulants, diabetes and reflux – associations with new diagnoses, and subsequent natural history, of idiopathic pulmonary fibrosis and other interstitial lung diseases: Analyses using the Optimum Patient Care Research Database (OPCRD)
Organisation:
University of Sydney
Study Registration:
Approval Date:
26 September 2023
ADEPT:
ADEPT0723
The impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care
Organisation:
UK Severe Asthma Registry
Study Registration:
Approval Date:
ADEPT:
ADEPT0120
Redefining severe asthma to high-risk asthma: Analysis of real-world data ot investigate patients who are at high risk of exacerbations, worsening of symptoms, and a loss of asthma control over time.
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
24 July 2023
ADEPT:
ADEPT0523
Implementation of a primary care asthma management quality improvement programme across 68 general practice sites
Organisation:
Optimum Patient Care Limited
Study Registration:
Approval Date:
ADEPT:
ADEPT1018
20/EM/0148
Identification of key opportunities for optimising the management of high-risk COPD patients in the UK using the CONQUEST Quality Standards: an observational longitudinal study
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
ADEPT0221
Defining clinical subtypes of adult asthma using electronic health records: analysis of a large UK primary care database with external validation
Organisation:
Asthma UK Centre for Applied Research
Study Registration:
Approval Date:
ADEPT:
ADEPT0619
Proactive risk management: A novel approach to embedding OCS stewardship into asthma care
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
Development and evaluation of clinical prediction models to estimate the risk of midgut
neuroendocrine tumours using statistical and machine learning approaches: an exploratory
study
Organisation:
Mendelian Health
Study Registration:
Approval Date:
5 September 2022
ADEPT:
ADEPT0822
An observational cohort study to describe intermittent oral corticosteroid use and its association with adverse events in asthma and An observational UK cohort study to describe intermittent oral corticosteroid prescribing patterns and their association with adverse outcomes in asthma
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
ISAC 20_000071
ADEPT1120
Using Electronic Health Records (EHR) for the development of Personalised Hormonal Therapy
Organisation:
Aveta Life
Study Registration:
Approval Date:
26 July 2022
ADEPT:
ADEPT0622
AFLOAT: Predicting the risk of Advanced non-alcoholic Fatty Liver Disease in cOmmunity patients with Abnormal Transaminases
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
29 June 2022
ADEPT:
ADEPT0522
Characteristics of Patients in Platform 19, a COVID-19 Research Database Combining Primary Care Electronic Health Record and Patient Reported Information.
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
ADEPT1720
Deriving asthma subtypes from electronic health records using statistical learning
Organisation:
Asthma UK Centre for Applied Research (AUKCAR)
Study Registration:
Approval Date:
16 August 2021
ADEPT:
ADEPT0619
Gallbladder pathology as an early sign of metachromatic leukodystrophy an exploratory study using electronic health records
Organisation:
Mendelian Health
Study Registration:
Approval Date:
9 December 2021
ADEPT:
ADEPT1821
Risk Predictors and Symptom Features of Long COVID Within a Broad Primary Care Patient Population Including Both Tested and Untested Patients
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
ADEPT1720
A retrospective observational study on characteristics, treatment patterns, and healthcare resource use of patients with xerostomia in primary care settings using Optimum Patient Care Research Database in United Kingdom
Organisation:
OPEN Health
Study Registration:
Approval Date:
9 December 2021
ADEPT:
ADEPT1921
A matched case control study to identify features associated with a group of rare diseases and examine the case identification accuracy of MendelScan, a rare disease case finding tool.
Organisation:
Mendelian Health
Study Registration:
Approval Date:
26 September 2021
ADEPT:
ADEPT1221
An exploratory study on epidemiological and genetic testing trends for retinitis pigmentosa and leber congenital amaurosis using primary care electronic records.
Organisation:
Mendelian Health
Study Registration:
Approval Date:
27 December 2021
ADEPT:
ADEPT1923
Unexplored associations with inflammatory skin conditions: a population-based cohort study of the risk of skin cancer, venous thromboembolism, and mental health conditions in atopic dermatitis and vitiligo
Organisation:
Momentum Data
Study Registration:
Approval Date:
14 July 2021
ADEPT:
ADEPT0721
The incidence of psychological comorbidities in paediatric and young adults with inflammatory bowel disease, and the impacts of mental health conditions on quality of life, disease severity and resource utilisation: a population-based cohort study in the UK
Organisation:
Momentum Data
Study Registration:
Approval Date:
27 December 2021
ADEPT:
ADEPT1922
Patient characteristics, treatment patterns, clinical outcomes, and health care resource utilization in severe asthma subgroups: A retrospective analysis of the International Severe Asthma Registry
Organisation:
Optimum Patient Care Global Limited (OPCG)
Study Registration:
Approval Date:
14 July 2021
ADEPT:
ADEPT0821
Maximizing Adherence and Gaining New Information For Your Chronic Obstructive Pulmonary Disease (MAGNIFY COPD): Study Protocol for the Pragmatic, Cluster Randomized Trial Evaluating the Impact of Dual Bronchodilator with Add-on Sensor and Electronic Monitoring on Clinical Outcomes
Organisation:
Observational & Pragmatic Research Institute (OPRI)
Study Registration:
Approval Date:
ADEPT:
ISRCTN10567920
19/EM/0238
ADEPT0719
Impact of Covid-19 using Platform C19: Describing a cohort of real-life patients during the Covid-19 pandemic and assessing the impact of Covid-19 and related behaviour on chronic conditions, and the effect of chronic conditions on Covid-19 outcomes.