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Publications

We have significantly contributed to the understanding of health conditions through real-world data analysis. The insights gained from these studies have had a positive impact on clinical practice, leading to more personalised and effective care for patients.

A machine learning algorithm for the detection of paroxysmal nocturnal haemoglobinuria (PNH) in UK primary care electronic health records

13 Oct 2024
Orphanet Journal of Rare Diseases

Authors:

Amanda Worker, Hadley Mahon, Jack Sams, Freya Boardman-Pretty, Elena Marchini, Rand Dubis, Alan Warren, Jez Stockdale, Jyothika Kumar, Elizabeth Varones, Daniel Ollerenshaw, Calum Grant, Peter Fish, Richard J Kelly
Keywords:
Machine learning, Paroxysmal Nocturnal Haemoglobinuria (PNH), Primary care, Rare disease, UK electronic health records
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Exacerbation history and blood eosinophil count prior to diagnosis of COPD and risk of subsequent exacerbations

3 Oct 2024
ERJ

Authors:

David M.G. Halpin , Heath Healey, Derek Skinner, Victoria Carter, Rachel Pullen, David Price
Keywords:
COPD, Exacerbation, Blood eosinophil count
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Children and Young Adults With Inflammatory Bowel Disease Have an Increased Incidence and Risk of Developing Mental Health Conditions: A UK Population-Based Cohort Study

1 Aug 2024
Inflamm Bowel Dis

Authors:

Rachel Cooney, Daniel Tang, Kevin Barrett, Richard K Russell
Keywords:
mental health, pediatric inflammatory bowel disease, psychiatry comorbidities
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Identifying patients with undiagnosed small intestinal neuroendocrine tumours in primary care using statistical and machine learning: model development and validation study

3 Jun 2024
Br J Cancer

Authors:

Ash Kieran Clift, Hadley Mahon, Ghazanfar Khan, Freya Boardman-Pretty, Amanda Worker, Elena Marchini, Orlando Buendia, Peter Fish, Mohid S Khan
Keywords:
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Budesonide/glycopyrrolate/formoterol for the management of COPD in a UK primary care population: real-world use and early medication success

24 May 2024
Int J of COPD

Authors:

Hana Müllerová, Jeffrey Shi Kai Chan, Heath Heatley, Victoria Carter, John Townend, Derek Skinner, Stefan Franzén, Jonathan Marshall, and David Price
Keywords:
Death, Exacerbation, Heart Failure, Myocardial Infarction, Pneumonia
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Impact of biologics initiation on oral corticosteroid use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: a pooled analysis of real-world data (SOLAR I)

26 Apr 2024
J Allergy Clin Immunol Pract

Authors:

Wenjia Chen, Trung N. Tran, John Townend, George C. Christoff, Ming-Ju Tsai, Alan Altraja, Belinda Cochrane, Borja G. Cosio, Martin Sivori, Ruth B. Murray, Michael P. Makris, Ghislaine Scelo, Lakmini Bulathsinhala, Ledit R. F. Ardusso, María Eugenia Franchi, Jorge Máspero, Fernando Saldarini, Ana María Stok, Ana Giselle Tomaszuk, Anahí Yañez, Benjamin Emmanuel, Cathy Emmas, Konstantinos Kostikas, Andrew N. Menzies-Gow, Neda Stjepanovic, Sinthia Z. Bosnic-Anticevich, Eve Denton, Peter G. Gibson, Mark Hew, Christine Jenkins, Peter G. Middleton, Matthew J. Peters, John W. Upham, Guy G. Brusselle, Renaud Louis, Florence Schleich, Paulo Márcio Pitrez, Todor A. Popov, Celine Bergeron, Mohit Bhutani, Kenneth R. Chapman, Andréanne Côté, Simon Couillard, Delbert R. Dorscheid, M. Diane Lougheed, Mohsen Sadatsafavi, Carlos Andrés Celis-Preciado, Libardo Jiménez-Maldonado, Bellanid Rodríguez-Cáceres, Diana Jimena Cano Rosales, Ivan Solarte, Carlos A. Torres-Duque, Susanne Hansen, Celeste M. Porsbjerg, Charlotte Suppli Ulrik, Arnaud Bourdin, Petros Bakakos, Konstantinos P. Exarchos, Athena Gogali, Aggelos A. Ladias, Nikolaos G. Papadopoulos, Andriana I. Papaioannou, Richard W. Costello, Breda Cushen, Patrick D. Mitchell, Giorgio Walter Canonica, Enrico Heffler, Francesca Puggioni, Takashi Iwanaga, Tatsuya Nagano, Yuji Tohda, Mona S. Al-Ahmad, Désirée Larenas-Linnemann, Bernt Bøgvald Aarli, Sverre Lehmann, Piotr Kuna, José Alberto Ferreira, João A. Fonseca, Cláudia Chaves Loureiro, Riyad Al-Lehebi, Adeeb A. Bulkhi, Yah Ru Juang, Mariko Siyue Koh, Anqi Liu, Chin Kook Rhee, Luis Perez-de-Llano, Pin-Kuei Fu, Diahn-Warng Perng, Chau-Chyun Sheu, Hao-Chien Wang, Bassam Mahboub, Laila Salameh, John Busby, Liam G. Heaney, David J. Jackson, Pujan H. Patel, Paul E. Pfeffer, Flavia Hoyte, Rohit Katial, Njira Lugogo, Roy Alton Pleasants, Eileen Wang, Michael E. Wechsler, Aaron Beastall, Victoria Carter, Nevaashni Eleangovan, Kirsty Fletton, David B. Price
Keywords:
Severe asthma, difficult-to-treat asthma, oral corticosteroids, steroids, biologics, monoclonal antibody, real-world evidence, anti-IL5, anti-IL4/13, anti-IgE
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